'Unexpected SMTP server response. Expected: 250, actual: 550, whole response: 550 5.7.1 Reject for policy reason'
This error tends to happen when a URL is used in a sent email and is flagged as Spam. This could have been in the email itself, but likely it will have been in the email signature. To test, we recommend removing the signature and sending a test email with only 'test' in the email body, then seeing if it sends fine. If it does, please get in touch with our team and we can ask Open X-Change to unlock this URL so you can send emails again normally.